Nick Freeman’s first-half goal handed Wycombe a deserved 1-0 win and sent struggling MK Dons bottom of Sky Bet League One.
Freeman fired home a fine volley just before half-time to earn Wanderers a third straight victory.
Liam Manning’s Dons slid to the foot of the table after a fifth loss on the spin.
The hosts went close early on when Max Stryjek saved smartly to keep out Nathan Holland and Zak Jules headed Josh McEachran’s measured cross narrowly over the crossbar.
At the other end, Chris Forino’s powerful header was well saved by Jamie Cumming.
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